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==================== THE KASABACH–MERRITT PHENOMENON  ==================== Large congenital hemangiomas may result in shunting of blood and high-output cardiac failure or entrapment of platelets and a thrombocytopenic coagulopathy and a potentially life-threatening hemorrhage (the Kasabach–Merritt syndrome or phenomenon) (Fig). The pathogenesis of congenital hemangiomas is poorly understood. There is an association with prematurity. Kasabach-Merritt phenomenon is a rare, life-threatening condition in which either of two specific vascular tumors (tufted angioma or kaposiform hemangioendothelioma) traps and destroys platelets, which are a component of blood that helps clotting. This condition is also associated with other abnormal clotting conditions in which there is excessive consumption of clotting factors. Kasabach-Merritt phenomenon does not occur in children with infantile hemangiomas. Tumors usually occur shortly after birth and are equally common in males and females. These ...
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Signe de SEIDEL
#INFO_MED
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**Le signe de #Seidel est synonyme de perforation de la #cornée. 
**Ce signe s'observe en instillant une goutte de #fluorescéine dans l'oeil et en l'éclairant à la lumière bleue. 
En cas de perforation, l'examinateur constate l'apparition d'une couleur #verte et l'#élimination de la goutte. 
**Cela est dû au fait que l'humeur aqueuse qui s'échappe de la plaie au niveau de l'oeil vient s'écouler sur la fluorescéine, modifie sa couleur et l'entraîne. 
**Le signe de Seidel est un signe #indiscutable de perforation cornéenne.

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=============== The bronze baby syndrome: A complication of  # phototherapy =============== **The Bronze baby syndrome is the dark grey-brown pigmentation of skin, mucous membrane and urine following phototherapy. **Hepatic dysfunction has to be there for this condition to be present. We report a neonate with dark brown pigmentation of skin. Lesions were spread over the abdomen (Fig. 1), chest, back and both upper and lower limb after receiving phototherapy for neonatal jaundice. **It is assumed that abnormal accumulation of photoisomer of bilirubin is the cause of this condition. **The second cause postulated is abnormal hepatic function leading to copper-porpyhrin complex which is photodestroyed leading to brown pigmentation. **The third explanation is accumulation of biliverdin leading to pigmentation. **It should be differentiated from grey baby syndrome exclusively seen in neonates and very young infants receiving high doses of chloramphenicol. The infant is cyanosed, acidot...
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==================== THE KASABACH–MERRITT PHENOMENON  ==================== Large congenital hemangiomas may result in shunting of blood and high-output cardiac failure or entrapment of platelets and a thrombocytopenic coagulopathy and a potentially life-threatening hemorrhage (the Kasabach–Merritt syndrome or phenomenon) (Fig). The pathogenesis of congenital hemangiomas is poorly understood. There is an association with prematurity. Kasabach-Merritt phenomenon is a rare, life-threatening condition in which either of two specific vascular tumors (tufted angioma or kaposiform hemangioendothelioma) traps and destroys platelets, which are a component of blood that helps clotting. This condition is also associated with other abnormal clotting conditions in which there is excessive consumption of clotting factors. Kasabach-Merritt phenomenon does not occur in children with infantile hemangiomas. Tumors usually occur shortly after birth and are equally common in males and females. These ...
Lire la suite